Riferimento farmaci
Chlordiazepoxide-clidinium
Chlordiazepoxide-clidinium is a medicine in the class gastrointestinal tract. It is used for irritable bowel syndrome.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: irritable bowel syndrome
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Forme farmaceutiche comuni
- compressa, capsula
- Dosaggi comuni
- 5 mg
- Interazioni note
- 231 (Maggiore: 65 · Moderata: 134 · Minore: 32)
- Nomi commerciali
- 11
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Chlordiazepoxide: Benzodiazepine; depresses all levels of CNS, including limbic and reticular formation, possibly by increasing gamma-aminobutyric acid (GABA) activity, a major inhibitory neurotransmitter. Clidinium: Anticholinergic agent; elicits antispasmodic and antisecretory effects on GI tract.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Peptic Ulcer, IBS, & Enterocolitis: 1-2 cap PO q6-8hr AC and HS
Gravidanza e allattamento
- Gravidanza
- Unsafe Chlordiazepoxide: late-pregnancy use can cause neonatal sedation, floppiness and withdrawal; no clear birth-defect risk. Clidinium (anticholinergic): no adequate data. Avoid, especially near term; use only if clearly needed.
- Allattamento
- Unknown Chlordiazepoxide: no milk data; it and its long-acting metabolites could sedate the infant (LactMed: prefer an alternative). Clidinium, an anticholinergic, may reduce milk supply. Prefer alternatives; if used, watch the infant for sedation and poor feeding and watch milk supply.
Effetti indesiderati segnalati
- Drowsiness
- Ataxia
- Xerostomia
Controindicazioni
- Hypersensitivity
- Glaucoma
- Prostatic hypertrophy
Chi deve prestare attenzione
- Contraindicated in Glaucoma, Prostatic hypertrophy, Severe respiratory depression.
- Concomitant use of benzodiazepines and opioids may result in profound respiratory depression, coma, and death.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (231)
- Alfentanil + Chlordiazepoxide-clidinium Major
- Alprazolam + Chlordiazepoxide-clidinium Major
- Amobarbital + Chlordiazepoxide-clidinium Major
- Belladonna and opium + Chlordiazepoxide-clidinium Major
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Major
- Brexanolone + Chlordiazepoxide-clidinium Major
- Buprenorphine + Chlordiazepoxide-clidinium Major
- Buprenorphine buccal + Chlordiazepoxide-clidinium Major
- Buprenorphine long-acting + Chlordiazepoxide-clidinium Major
- Buprenorphine subdermal implant + Chlordiazepoxide-clidinium Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Chlordiazepoxide-clidinium used for?
Chlordiazepoxide-clidinium is a medicine in the class gastrointestinal tract. It is used for Irritable bowel syndrome, Peptic ulcer.
What side effects have been reported with Chlordiazepoxide-clidinium?
Drowsiness, Ataxia, Xerostomia.
Can Chlordiazepoxide-clidinium be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Chlordiazepoxide: late-pregnancy use can cause neonatal sedation, floppiness and withdrawal; no clear birth-defect risk. Clidinium (anticholinergic): no adequate data. Avoid, especially near term; use only if clearly needed. Breastfeeding: Unknown. Chlordiazepoxide: no milk data; it and its long-acting metabolites could sedate the infant (LactMed: prefer an alternative). Clidinium, an anticholinergic, may reduce milk supply. Prefer alternatives; if used, watch the infant for sedation and poor feeding and watch milk supply.
What does Chlordiazepoxide-clidinium interact with?
MediHelp lists 231 known interactions for Chlordiazepoxide-clidinium. Major: 65 · Moderate: 134 · Minor: 32. The most serious include Alfentanil, Alprazolam, Amobarbital.
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