Interazioni tra farmaci
Buprenorphine subdermal implant + Chlordiazepoxide-clidinium
Gravità: Maggiore
Buprenorphine subdermal implant and Chlordiazepoxide-clidinium: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Buprenorphine with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The implant gives continuous exposure that cannot be quickly withdrawn.
Cosa significa questa interazione in parole semplici
Buprenorphine subdermal implant and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive CNS and respiratory depression from opioid and benzodiazepine effects.
Cosa fare
Use together only when alternatives are inadequate, and keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Buprenorphine subdermal implant e Chlordiazepoxide-clidinium, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Maggiore
- Alprazolam + Chlordiazepoxide-clidinium Maggiore
- Amobarbital + Chlordiazepoxide-clidinium Maggiore
- Belladonna and opium + Chlordiazepoxide-clidinium Maggiore
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Maggiore
- Brexanolone + Chlordiazepoxide-clidinium Maggiore
Domande frequenti
Can I take Buprenorphine subdermal implant with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The implant gives continuous exposure that cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine subdermal implant and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
