Interazioni tra farmaci
Cabazitaxel + Clarithromycin
Gravità: Maggiore
Cabazitaxel and Clarithromycin: major interaction.
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Sintesi
Clarithromycin is a strong CYP3A4 inhibitor and can raise cabazitaxel exposure. Higher levels increase the risk of neutropenia, diarrhea and other dose-related toxicity.
Cosa significa questa interazione in parole semplici
Cabazitaxel and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Perché avviene
Inhibition of CYP3A4-mediated metabolism of cabazitaxel by clarithromycin.
Cosa fare
Avoid the combination and use a non-interacting antibiotic such as azithromycin if feasible. If it cannot be avoided, consider reducing the cabazitaxel dose and monitor blood counts closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Cabazitaxel
- Adenovirus types 4 and 7 live + Cabazitaxel Maggiore
- Atazanavir + Cabazitaxel Maggiore
- Bcg intravesical live + Cabazitaxel Maggiore
- Bcg vaccine live + Cabazitaxel Maggiore
- Cabazitaxel + Carbamazepine Maggiore
- Cabazitaxel + Conivaptan Maggiore
Domande frequenti
Can I take Cabazitaxel with Clarithromycin?
MediHelp rates the interaction as major. Cabazitaxel and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin is a strong CYP3A4 inhibitor and can raise cabazitaxel exposure. Higher levels increase the risk of neutropenia, diarrhea and other dose-related toxicity.
How serious is the interaction between Cabazitaxel and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-interacting antibiotic such as azithromycin if feasible. If it cannot be avoided, consider reducing the cabazitaxel dose and monitor blood counts closely.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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