Interazioni tra farmaci
Clarithromycin + Dihydroergotamine
Gravità: Controindicata
Clarithromycin and Dihydroergotamine: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Clarithromycin raises dihydroergotamine concentrations and can precipitate ergotism, with severe peripheral and cerebral vasospasm and ischemia. This is a well-documented, potentially limb- or life-threatening interaction.
Cosa significa questa interazione in parole semplici
Clarithromycin and Dihydroergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Dihydroergotamine belongs to Central Nervous System.
Perché avviene
Clarithromycin inhibits CYP3A4, reducing metabolism of dihydroergotamine.
Cosa fare
Do not use together; choose a non-CYP3A4-inhibiting antibiotic such as azithromycin, and seek urgent care if numbness, coldness or ischemic symptoms appear.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine intranasal Controindicata
Altre interazioni di Dihydroergotamine
- Almotriptan + Dihydroergotamine Controindicata
- Dihydroergotamine + Dopamine Controindicata
- Dihydroergotamine + Dronedarone Controindicata
- Dihydroergotamine + Efavirenz Controindicata
- Dihydroergotamine + Eletriptan Controindicata
- Dihydroergotamine + Ergotamine Controindicata
Domande frequenti
Can I take Clarithromycin with Dihydroergotamine?
MediHelp rates the interaction as contraindicated. Clarithromycin and Dihydroergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin raises dihydroergotamine concentrations and can precipitate ergotism, with severe peripheral and cerebral vasospasm and ischemia. This is a well-documented, potentially limb- or life-threatening interaction.
How serious is the interaction between Clarithromycin and Dihydroergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-CYP3A4-inhibiting antibiotic such as azithromycin, and seek urgent care if numbness, coldness or ischemic symptoms appear.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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