Interazioni tra farmaci
Calcium / magnesium / potassium / sodium oxybates + Clonazepam
Gravità: Controindicata
Calcium / magnesium / potassium / sodium oxybates and Clonazepam: contraindicated interaction.
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Sintesi
Oxybates are potent CNS depressants and combining them with benzodiazepines increases the risk of profound sedation, respiratory depression, coma and death. Oxybate labeling advises against concurrent use with sedative hypnotics.
Cosa significa questa interazione in parole semplici
Calcium / magnesium / potassium / sodium oxybates and Clonazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
Cosa fare
Avoid the combination; replace the benzodiazepine or reconsider the oxybate. If unavoidable, use minimal doses with close monitoring of consciousness and respiration.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clonazepam
- Clonazepam + Sodium oxybate Controindicata
- Alfentanil + Clonazepam Maggiore
- Alprazolam + Clonazepam Maggiore
- Amobarbital + Clonazepam Maggiore
- Belladonna and opium + Clonazepam Maggiore
- Benzhydrocodone / acetaminophen + Clonazepam Maggiore
Domande frequenti
Can I take Calcium / magnesium / potassium / sodium oxybates with Clonazepam?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Clonazepam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants and combining them with benzodiazepines increases the risk of profound sedation, respiratory depression, coma and death. Oxybate labeling advises against concurrent use with sedative hypnotics.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Clonazepam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; replace the benzodiazepine or reconsider the oxybate. If unavoidable, use minimal doses with close monitoring of consciousness and respiration.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Sodium oxybate, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
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