Interazioni tra farmaci
Clonazepam + Sodium oxybate
Gravità: Controindicata
Clonazepam and Sodium oxybate: contraindicated interaction.
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Sintesi
Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
Cosa significa questa interazione in parole semplici
Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clonazepam belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.
Perché avviene
Additive CNS and respiratory depression via GABA-B agonism from oxybate and GABA-A potentiation from clonazepam.
Cosa fare
Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Controindicata
- Alfentanil + Clonazepam Maggiore
- Alprazolam + Clonazepam Maggiore
- Amobarbital + Clonazepam Maggiore
- Belladonna and opium + Clonazepam Maggiore
- Benzhydrocodone / acetaminophen + Clonazepam Maggiore
Altre interazioni di Sodium oxybate
- Alprazolam + Sodium oxybate Controindicata
- Amobarbital + Sodium oxybate Controindicata
- Butorphanol + Sodium oxybate Controindicata
- Chloral hydrate + Sodium oxybate Controindicata
- Clorazepate + Sodium oxybate Controindicata
- Eszopiclone + Sodium oxybate Controindicata
Domande frequenti
Can I take Clonazepam with Sodium oxybate?
MediHelp rates the interaction as contraindicated. Clonazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate is a strong CNS depressant and combining it with a benzodiazepine increases the risk of profound sedation, respiratory depression, coma and death. Labeling advises against concomitant use with sedative hypnotics.
How serious is the interaction between Clonazepam and Sodium oxybate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative to the benzodiazepine. If unavoidable, use minimal doses with close monitoring of consciousness and breathing.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Clonazepam page.
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