Interazioni tra farmaci
Calcium / magnesium / potassium / sodium oxybates + Cyclizine
Gravità: Maggiore
Calcium / magnesium / potassium / sodium oxybates and Cyclizine: major interaction.
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Sintesi
Oxybate salts cause marked CNS and respiratory depression, and cyclizine is a sedating antihistamine. Combined use can result in profound sedation, respiratory depression, coma and death.
Cosa significa questa interazione in parole semplici
Calcium / magnesium / potassium / sodium oxybates and Cyclizine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Additive CNS and respiratory depression through pharmacodynamic synergism.
Cosa fare
Avoid concurrent use where alternatives exist; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cyclizine
- Cyclizine + Henbane Maggiore
- Cyclizine + Sodium oxybate Maggiore
- Abobotulinumtoxina + Cyclizine Moderata
- Alfentanil + Cyclizine Moderata
- Alprazolam + Cyclizine Moderata
- Amantadine + Cyclizine Moderata
Domande frequenti
Can I take Calcium / magnesium / potassium / sodium oxybates with Cyclizine?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Cyclizine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybate salts cause marked CNS and respiratory depression, and cyclizine is a sedating antihistamine. Combined use can result in profound sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Cyclizine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where alternatives exist; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Henbane, Sodium oxybate, Abobotulinumtoxina. The full list is on the Cyclizine page.
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