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Interazioni tra farmaci

Candesartan-hydrochlorothiazide + Chlorthalidone

Gravità: Maggiore

Candesartan-hydrochlorothiazide and Chlorthalidone: major interaction.

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Sintesi

Chlorthalidone and hydrochlorothiazide are both thiazide-type diuretics, so using them together duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia.

Cosa significa questa interazione in parole semplici

Candesartan-hydrochlorothiazide and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.

Livello di evidenza: Moderate

Perché avviene

Therapeutic duplication with additive inhibition of the distal tubule sodium-chloride cotransporter.

Cosa fare

Avoid concurrent use and keep to a single thiazide-type agent. If both have been used, check electrolytes and renal function.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Candesartan-hydrochlorothiazide with Chlorthalidone?

MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorthalidone and hydrochlorothiazide are both thiazide-type diuretics, so using them together duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia.

How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorthalidone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to a single thiazide-type agent. If both have been used, check electrolytes and renal function.

What other medicines interact with Candesartan-hydrochlorothiazide?

MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.

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