Interazioni tra farmaci
Carbenoxolone + Chlorthalidone
Gravità: Maggiore
Carbenoxolone and Chlorthalidone: major interaction.
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Sintesi
Carbenoxolone has mineralocorticoid-like activity and causes sodium retention and potassium loss. With chlorthalidone, the risk of marked hypokalemia and fluid retention is increased.
Cosa significa questa interazione in parole semplici
Carbenoxolone and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, enhancing mineralocorticoid effect on renal potassium excretion, which adds to diuretic potassium wasting.
Cosa fare
Avoid the combination if possible; otherwise monitor serum potassium and blood pressure frequently and replace potassium as needed.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Chlorthalidone
Domande frequenti
Can I take Carbenoxolone with Chlorthalidone?
MediHelp rates the interaction as major. Carbenoxolone and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity and causes sodium retention and potassium loss. With chlorthalidone, the risk of marked hypokalemia and fluid retention is increased.
How serious is the interaction between Carbenoxolone and Chlorthalidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor serum potassium and blood pressure frequently and replace potassium as needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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