Interazioni tra farmaci
Capecitabine + Dengue vaccine
Gravità: Maggiore
Capecitabine and Dengue vaccine: major interaction.
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Sintesi
Dengue vaccine is a live attenuated vaccine, and capecitabine-induced immunosuppression may both reduce the immune response and increase the risk of vaccine-related infection. Vaccination during chemotherapy is generally inappropriate.
Cosa significa questa interazione in parole semplici
Capecitabine and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Cytotoxic immunosuppression impairs response to the vaccine and permits replication of live attenuated virus.
Cosa fare
Avoid live vaccines during chemotherapy and give them only after immune recovery as advised by the specialist team.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Capecitabine
Domande frequenti
Can I take Capecitabine with Dengue vaccine?
MediHelp rates the interaction as major. Capecitabine and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and capecitabine-induced immunosuppression may both reduce the immune response and increase the risk of vaccine-related infection. Vaccination during chemotherapy is generally inappropriate.
How serious is the interaction between Capecitabine and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and give them only after immune recovery as advised by the specialist team.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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