Interazioni tra farmaci
Arsenic trioxide + Capecitabine
Gravità: Maggiore
Arsenic trioxide and Capecitabine: major interaction.
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Sintesi
Arsenic trioxide markedly prolongs the QT interval and can cause torsades de pointes. Fluorouracil-class drugs have rare reports of cardiotoxicity, so the combination adds uncertain additional risk on top of a high baseline risk.
Cosa significa questa interazione in parole semplici
Arsenic trioxide and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Capecitabine belongs to Oncology.
Perché avviene
Arsenic trioxide blocks cardiac repolarization currents; capecitabine contribution to QT effect is weak and not well established.
Cosa fare
Check baseline ECG and keep potassium and magnesium within normal range. Monitor ECG during treatment and avoid other QT-prolonging drugs.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Capecitabine
Altre interazioni di Arsenic trioxide
- Amiodarone + Arsenic trioxide Controindicata
- Amisulpride + Arsenic trioxide Controindicata
- Arsenic trioxide + Clomipramine Controindicata
- Arsenic trioxide + Dronedarone Controindicata
- Arsenic trioxide + Fluphenazine Controindicata
- Arsenic trioxide + Gemifloxacin Controindicata
Domande frequenti
Can I take Arsenic trioxide with Capecitabine?
MediHelp rates the interaction as major. Arsenic trioxide and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and can cause torsades de pointes. Fluorouracil-class drugs have rare reports of cardiotoxicity, so the combination adds uncertain additional risk on top of a high baseline risk.
How serious is the interaction between Arsenic trioxide and Capecitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and keep potassium and magnesium within normal range. Monitor ECG during treatment and avoid other QT-prolonging drugs.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Capecitabine page.
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