Interazioni tra farmaci
Carbamazepine + Nirmatrelvir
Gravità: Controindicata
Carbamazepine and Nirmatrelvir: contraindicated interaction.
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Sintesi
Carbamazepine markedly lowers nirmatrelvir concentrations, risking loss of antiviral efficacy against SARS-CoV-2 and possible resistance. The inducing effect persists after carbamazepine is stopped.
Cosa significa questa interazione in parole semplici
Carbamazepine and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Nirmatrelvir belongs to Anti Virals.
Perché avviene
Carbamazepine induces CYP3A4, accelerating nirmatrelvir metabolism.
Cosa fare
Do not use together; consider another COVID-19 antiviral not affected by inducers. Allow a washout of the inducer before starting nirmatrelvir.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Carbamazepine
- Artemether / lumefantrine + Carbamazepine Controindicata
- Cabotegravir + Carbamazepine Controindicata
- Carbamazepine + Delamanid Controindicata
- Carbamazepine + Dienogest / estradiol valerate Controindicata
- Carbamazepine + Doravirine Controindicata
- Carbamazepine + Elbasvir / grazoprevir Controindicata
Altre interazioni di Nirmatrelvir
- Alfuzosin + Nirmatrelvir Controindicata
- Amiodarone + Nirmatrelvir Controindicata
- Apalutamide + Nirmatrelvir Controindicata
- Colchicine + Nirmatrelvir Controindicata
- Dronedarone + Nirmatrelvir Controindicata
- Enzalutamide + Nirmatrelvir Controindicata
Domande frequenti
Can I take Carbamazepine with Nirmatrelvir?
MediHelp rates the interaction as contraindicated. Carbamazepine and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine markedly lowers nirmatrelvir concentrations, risking loss of antiviral efficacy against SARS-CoV-2 and possible resistance. The inducing effect persists after carbamazepine is stopped.
How serious is the interaction between Carbamazepine and Nirmatrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider another COVID-19 antiviral not affected by inducers. Allow a washout of the inducer before starting nirmatrelvir.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
