Interazioni tra farmaci
Dronedarone + Nirmatrelvir
Gravità: Controindicata
Dronedarone and Nirmatrelvir: contraindicated interaction.
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Sintesi
Nirmatrelvir is a CYP3A4 inhibitor and is given with ritonavir, which further boosts inhibition. Dronedarone levels can rise substantially, increasing the risk of proarrhythmia and QT prolongation.
Cosa significa questa interazione in parole semplici
Dronedarone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.
Perché avviene
Inhibition of CYP3A4 reduces dronedarone clearance.
Cosa fare
Avoid the combination; consider withholding dronedarone during antiviral treatment only under specialist guidance, or use an alternative COVID-19 therapy.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Dronedarone
- Adagrasib + Dronedarone Controindicata
- Amiodarone + Dronedarone Controindicata
- Arsenic trioxide + Dronedarone Controindicata
- Artemether / lumefantrine + Dronedarone Controindicata
- Atazanavir + Dronedarone Controindicata
- Azithromycin + Dronedarone Controindicata
Altre interazioni di Nirmatrelvir
- Alfuzosin + Nirmatrelvir Controindicata
- Amiodarone + Nirmatrelvir Controindicata
- Apalutamide + Nirmatrelvir Controindicata
- Carbamazepine + Nirmatrelvir Controindicata
- Colchicine + Nirmatrelvir Controindicata
- Enzalutamide + Nirmatrelvir Controindicata
Domande frequenti
Can I take Dronedarone with Nirmatrelvir?
MediHelp rates the interaction as contraindicated. Dronedarone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nirmatrelvir is a CYP3A4 inhibitor and is given with ritonavir, which further boosts inhibition. Dronedarone levels can rise substantially, increasing the risk of proarrhythmia and QT prolongation.
How serious is the interaction between Dronedarone and Nirmatrelvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider withholding dronedarone during antiviral treatment only under specialist guidance, or use an alternative COVID-19 therapy.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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