Interazioni tra farmaci
Carbidopa-entacapone-levodopa + Sapropterin
Gravità: Moderata
Carbidopa-entacapone-levodopa and Sapropterin: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
Cosa significa questa interazione in parole semplici
Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
Perché avviene
Not firmly established; possibly enhanced dopaminergic and nitric oxide pathway activity.
Cosa fare
Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Carbidopa-entacapone-levodopa e Sapropterin, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Controindicata
- Carbidopa-entacapone-levodopa + Phenelzine Controindicata
- Carbidopa-entacapone-levodopa + Selegiline transdermal Controindicata
- Carbidopa-entacapone-levodopa + Tranylcypromine Controindicata
- Amisulpride + Carbidopa-entacapone-levodopa Maggiore
- Asenapine transdermal + Carbidopa-entacapone-levodopa Maggiore
Altre interazioni di Sapropterin
- Avanafil + Sapropterin Moderata
- Carbidopa-levodopa + Sapropterin Moderata
- Levodopa + Sapropterin Moderata
- Methotrexate + Sapropterin Moderata
- Phenobarbitone + Sapropterin Moderata
- Pyrimethamine + Sapropterin Moderata
Domande frequenti
Can I take Carbidopa-entacapone-levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
How serious is the interaction between Carbidopa-entacapone-levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
