Interazioni tra farmaci
Carbidopa-entacapone-levodopa + Isocarboxazid
Gravità: Controindicata
Carbidopa-entacapone-levodopa and Isocarboxazid: contraindicated interaction.
Ultimo aggiornamento
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Sintesi
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
Cosa significa questa interazione in parole semplici
Carbidopa-entacapone-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Perché avviene
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines with additional COMT inhibition
Cosa fare
Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Phenelzine Controindicata
- Carbidopa-entacapone-levodopa + Selegiline transdermal Controindicata
- Carbidopa-entacapone-levodopa + Tranylcypromine Controindicata
- Amisulpride + Carbidopa-entacapone-levodopa Maggiore
- Asenapine transdermal + Carbidopa-entacapone-levodopa Maggiore
- Carbidopa-entacapone-levodopa + Chlorpromazine Maggiore
Altre interazioni di Isocarboxazid
- 5-HTP + Isocarboxazid Controindicata
- Amitriptyline + Isocarboxazid Controindicata
- Amobarbital + Isocarboxazid Controindicata
- Amoxapine + Isocarboxazid Controindicata
- Apraclonidine + Isocarboxazid Controindicata
- Atomoxetine + Isocarboxazid Controindicata
Domande frequenti
Can I take Carbidopa-entacapone-levodopa with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Carbidopa-entacapone-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-entacapone-levodopa and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Phenelzine, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-entacapone-levodopa page.
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