Interazioni tra farmaci
Caspofungin + Cyclosporine
Gravità: Moderata
Caspofungin and Cyclosporine: moderate interaction.
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Sintesi
Cyclosporine increases caspofungin exposure, and transient rises in liver transaminases have been seen when the two are given together. Caspofungin does not meaningfully change cyclosporine levels.
Cosa significa questa interazione in parole semplici
Caspofungin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Cyclosporine inhibits OATP-mediated hepatic uptake of caspofungin, raising its plasma concentrations.
Cosa fare
Monitor liver enzymes during coadministration and consider stopping if significant hepatic abnormalities develop.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Caspofungin
- Apalutamide + Caspofungin Moderata
- Carbamazepine + Caspofungin Moderata
- Caspofungin + Cyclosporin Moderata
- Caspofungin + Dexamethasone Moderata
- Caspofungin + Efavirenz Moderata
- Caspofungin + Fosphenytoin Moderata
Domande frequenti
Can I take Caspofungin with Cyclosporine?
MediHelp rates the interaction as moderate. Caspofungin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases caspofungin exposure, and transient rises in liver transaminases have been seen when the two are given together. Caspofungin does not meaningfully change cyclosporine levels.
How serious is the interaction between Caspofungin and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during coadministration and consider stopping if significant hepatic abnormalities develop.
What other medicines interact with Caspofungin?
MediHelp also lists interactions of Caspofungin with, for example, Apalutamide, Carbamazepine, Cyclosporin. The full list is on the Caspofungin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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