Interazioni tra farmaci
Caspofungin + Cyclosporin
Gravità: Moderata
Caspofungin and Cyclosporin: moderate interaction.
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Sintesi
Cyclosporine raises caspofungin exposure, and transient elevations of liver transaminases have been seen with the combination. Caspofungin does not materially change cyclosporine levels.
Cosa significa questa interazione in parole semplici
Caspofungin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caspofungin belongs to Anti Fungals; Cyclosporin belongs to Miscellaneous.
Perché avviene
Cyclosporine inhibits OATP1B1-mediated hepatic uptake of caspofungin, raising its plasma concentrations.
Cosa fare
Monitor liver enzymes during concurrent therapy and discontinue if clinically significant hepatotoxicity develops.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Caspofungin
- Apalutamide + Caspofungin Moderata
- Carbamazepine + Caspofungin Moderata
- Caspofungin + Cyclosporine Moderata
- Caspofungin + Dexamethasone Moderata
- Caspofungin + Efavirenz Moderata
- Caspofungin + Fosphenytoin Moderata
Domande frequenti
Can I take Caspofungin with Cyclosporin?
MediHelp rates the interaction as moderate. Caspofungin and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine raises caspofungin exposure, and transient elevations of liver transaminases have been seen with the combination. Caspofungin does not materially change cyclosporine levels.
How serious is the interaction between Caspofungin and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes during concurrent therapy and discontinue if clinically significant hepatotoxicity develops.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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