Interazioni tra farmaci
Cefepime + Kanamycin
Gravità: Moderata
Cefepime and Kanamycin: moderate interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Both drugs are cleared by the kidney, and aminoglycosides are well known for kidney and inner-ear toxicity. Cefepime on top of kanamycin may add to renal stress, and reduced renal function in turn raises aminoglycoside levels and the risk of ototoxicity. Cefepime itself can accumulate and cause neurotoxicity when kidney function falls.
Cosa significa questa interazione in parole semplici
Cefepime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Additive potential nephrotoxicity, with reduced renal clearance of both agents if kidney injury develops.
Cosa fare
Monitor serum creatinine and urine output regularly and adjust cefepime dose to renal function. Check kanamycin levels where available and watch for hearing or balance changes.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Cefepime e Kanamycin, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Cefepime
- Amikacin + Cefepime Moderata
- Cefepime + Cholera vaccine Moderata
- Cefepime + Dexamethasone-tobramycin Moderata
- Cefepime + Gentamicin Moderata
- Cefepime + Microbiota Moderata
- Cefepime + Plazomicin Moderata
Domande frequenti
Can I take Cefepime with Kanamycin?
MediHelp rates the interaction as moderate. Cefepime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are cleared by the kidney, and aminoglycosides are well known for kidney and inner-ear toxicity. Cefepime on top of kanamycin may add to renal stress, and reduced renal function in turn raises aminoglycoside levels and the risk of ototoxicity. Cefepime itself can accumulate and cause neurotoxicity when kidney function falls.
How serious is the interaction between Cefepime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output regularly and adjust cefepime dose to renal function. Check kanamycin levels where available and watch for hearing or balance changes.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
