Interazioni tra farmaci
Cefepime + Plazomicin
Gravità: Moderata
Cefepime and Plazomicin: moderate interaction.
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Sintesi
Plazomicin is an aminoglycoside with known nephrotoxicity, ototoxicity and neuromuscular blockade risk, and both drugs depend on renal elimination. Combining with cefepime may add to renal stress, and any decline in kidney function would increase plazomicin exposure and cefepime-related neurotoxicity.
Cosa significa questa interazione in parole semplici
Cefepime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefepime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Perché avviene
Additive potential nephrotoxicity with reduced renal clearance of both drugs if kidney injury occurs.
Cosa fare
Monitor serum creatinine and plazomicin concentrations per labeling, and adjust doses of both drugs to renal function. Assess hearing and neurologic status during therapy.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cefepime
- Amikacin + Cefepime Moderata
- Cefepime + Cholera vaccine Moderata
- Cefepime + Dexamethasone-tobramycin Moderata
- Cefepime + Gentamicin Moderata
- Cefepime + Kanamycin Moderata
- Cefepime + Microbiota Moderata
Altre interazioni di Plazomicin
- Cefaclor + Plazomicin Moderata
- Cefadroxil + Plazomicin Moderata
- Cefalexin + Plazomicin Moderata
- Cefazolin + Plazomicin Moderata
- Cefditoren + Plazomicin Moderata
- Cefixime + Plazomicin Moderata
Domande frequenti
Can I take Cefepime with Plazomicin?
MediHelp rates the interaction as moderate. Cefepime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is an aminoglycoside with known nephrotoxicity, ototoxicity and neuromuscular blockade risk, and both drugs depend on renal elimination. Combining with cefepime may add to renal stress, and any decline in kidney function would increase plazomicin exposure and cefepime-related neurotoxicity.
How serious is the interaction between Cefepime and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations per labeling, and adjust doses of both drugs to renal function. Assess hearing and neurologic status during therapy.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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