Interazioni tra farmaci
Celecoxib + Pemetrexed
Gravità: Maggiore
Celecoxib and Pemetrexed: major interaction.
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Sintesi
NSAIDs can reduce renal clearance of pemetrexed, raising its exposure and the risk of myelosuppression, renal toxicity and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment. Celecoxib has a relatively long half-life, so the effect can persist.
Cosa significa questa interazione in parole semplici
Celecoxib and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Perché avviene
NSAID-induced reduction in renal prostaglandin-dependent perfusion and glomerular filtration decreases renal elimination of pemetrexed.
Cosa fare
Where possible, hold celecoxib in the days before, on the day of and after pemetrexed, following the labeling schedule for long half-life NSAIDs. If it cannot be avoided, monitor blood counts and renal function closely.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Celecoxib
- Celecoxib + Ketorolac Controindicata
- Celecoxib + Ketorolac intranasal Controindicata
- Aceclofenac + Celecoxib Maggiore
- Acemetacin + Celecoxib Maggiore
- Amiloride + Celecoxib Maggiore
- Apixaban + Celecoxib Maggiore
Altre interazioni di Pemetrexed
- Bacitracin + Pemetrexed Maggiore
- Brexucabtagene autoleucel + Pemetrexed Maggiore
- Ciltacabtagene autoleucel + Pemetrexed Maggiore
- Deferiprone + Pemetrexed Maggiore
- Dengue vaccine + Pemetrexed Maggiore
- Diclofenac + Pemetrexed Maggiore
Domande frequenti
Can I take Celecoxib with Pemetrexed?
MediHelp rates the interaction as major. Celecoxib and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce renal clearance of pemetrexed, raising its exposure and the risk of myelosuppression, renal toxicity and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment. Celecoxib has a relatively long half-life, so the effect can persist.
How serious is the interaction between Celecoxib and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, hold celecoxib in the days before, on the day of and after pemetrexed, following the labeling schedule for long half-life NSAIDs. If it cannot be avoided, monitor blood counts and renal function closely.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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