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Interazioni tra farmaci

Celecoxib + Ketorolac

Gravità: Controindicata

Celecoxib and Ketorolac: contraindicated interaction.

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Sintesi

Ketorolac is contraindicated with other NSAIDs, and celecoxib adds cyclo-oxygenase inhibition on top of ketorolac's. Gastrointestinal bleeding, renal injury and cardiovascular events are more likely without additional analgesic benefit.

Cosa significa questa interazione in parole semplici

Celecoxib and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Celecoxib belongs to Musculoskeletal; Ketorolac belongs to Musculoskeletal.

Livello di evidenza: High

Perché avviene

Additive COX inhibition causing gastrointestinal, renal and platelet effects

Cosa fare

Do not use together; use one NSAID only, or add paracetamol or an opioid for additional analgesia.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Celecoxib with Ketorolac?

MediHelp rates the interaction as contraindicated. Celecoxib and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with other NSAIDs, and celecoxib adds cyclo-oxygenase inhibition on top of ketorolac's. Gastrointestinal bleeding, renal injury and cardiovascular events are more likely without additional analgesic benefit.

How serious is the interaction between Celecoxib and Ketorolac?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use one NSAID only, or add paracetamol or an opioid for additional analgesia.

What other medicines interact with Ketorolac?

MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.

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