Interazioni tra farmaci
Chloramphenicol + Vitamin B12
Gravità: Moderata
Chloramphenicol and Vitamin B12: moderate interaction.
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Sintesi
Chloramphenicol can suppress bone marrow, which may delay or blunt the hematologic response to vitamin B12 in patients being treated for pernicious or megaloblastic anemia. The effect is described in case reports and has clinical relevance mainly in deficient patients.
Cosa significa questa interazione in parole semplici
Chloramphenicol and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vitamin B12 belongs to Gastrointestinal Tract.
Perché avviene
Chloramphenicol-induced bone marrow suppression counteracts the erythropoietic response to B12 replacement.
Cosa fare
Monitor reticulocyte count and hemoglobin in B12-deficient patients receiving chloramphenicol. Use an alternative antibiotic if the expected hematologic response fails to appear.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Vitamin B12
Altre interazioni di Chloramphenicol
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- Benzhydrocodone / acetaminophen + Chloramphenicol Maggiore
- Chloramphenicol + Cobimetinib Maggiore
- Chloramphenicol + Colchicine Maggiore
Domande frequenti
Can I take Chloramphenicol with Vitamin B12?
MediHelp rates the interaction as moderate. Chloramphenicol and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can suppress bone marrow, which may delay or blunt the hematologic response to vitamin B12 in patients being treated for pernicious or megaloblastic anemia. The effect is described in case reports and has clinical relevance mainly in deficient patients.
How serious is the interaction between Chloramphenicol and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor reticulocyte count and hemoglobin in B12-deficient patients receiving chloramphenicol. Use an alternative antibiotic if the expected hematologic response fails to appear.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Dichlorphenamide, Metformin, Neomycin po. The full list is on the Vitamin B12 page.
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