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Interazioni tra farmaci

Cholera vaccine + Cilastatin-imipenem

Gravità: Moderata

Cholera vaccine and Cilastatin-imipenem: moderate interaction.

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Sintesi

Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.

Cosa significa questa interazione in parole semplici

Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Livello di evidenza: Moderate

Perché avviene

Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.

Cosa fare

Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.

Cosa chiedere al farmacista

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Cholera vaccine with Cilastatin-imipenem?

MediHelp rates the interaction as moderate. Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.

How serious is the interaction between Cholera vaccine and Cilastatin-imipenem?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.

What other medicines interact with Cilastatin-imipenem?

MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.

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