Drug interactions
Cholera vaccine + Cilastatin-imipenem
Severity: Moderate
Cholera vaccine and Cilastatin-imipenem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
What this interaction means in plain words
Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
What to do
Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilastatin-imipenem
Frequently asked questions
Can I take Cholera vaccine with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Cholera vaccine and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral cholera vaccine depends on gut colonization by the attenuated strain. Imipenem is a broad-spectrum antibiotic that may eliminate the strain and reduce the vaccine response. This could leave the patient inadequately protected.
How serious is the interaction between Cholera vaccine and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination within 14 days after systemic antibiotics, per labeling. Postpone elective vaccination or revaccinate after the course ends.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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