Interazioni tra farmaci
Cilastatin-imipenem + Sodium picosulfate
Gravità: Moderata
Cilastatin-imipenem and Sodium picosulfate: moderate interaction.
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Sintesi
Sodium picosulfate is a prodrug that needs colonic bacteria to be converted to its active laxative form. Systemic antibiotics such as imipenem may disturb the colonic flora and reduce this activation, which can lead to a poorer bowel cleansing result before colonoscopy.
Cosa significa questa interazione in parole semplici
Cilastatin-imipenem and Sodium picosulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Antibiotic-induced suppression of colonic bacteria reduces conversion of picosulfate to its active metabolite.
Cosa fare
Where possible, avoid scheduling bowel preparation during an antibiotic course, or confirm the quality of bowel cleansing before the procedure. Consider an alternative preparation not dependent on bacterial activation if cleansing is likely to be inadequate.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cilastatin-imipenem
Domande frequenti
Can I take Cilastatin-imipenem with Sodium picosulfate?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Sodium picosulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to be converted to its active laxative form. Systemic antibiotics such as imipenem may disturb the colonic flora and reduce this activation, which can lead to a poorer bowel cleansing result before colonoscopy.
How serious is the interaction between Cilastatin-imipenem and Sodium picosulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid scheduling bowel preparation during an antibiotic course, or confirm the quality of bowel cleansing before the procedure. Consider an alternative preparation not dependent on bacterial activation if cleansing is likely to be inadequate.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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