Interazioni tra farmaci
Clarithromycin + Eletriptan
Gravità: Controindicata
Clarithromycin and Eletriptan: contraindicated interaction.
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Sintesi
Clarithromycin is a strong CYP3A4 inhibitor, and eletriptan is cleared largely by CYP3A4. Raised eletriptan exposure can lead to excessive eletriptan effect, including vasoconstriction and coronary spasm.
Cosa significa questa interazione in parole semplici
Clarithromycin and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Eletriptan belongs to Central Nervous System.
Perché avviene
CYP3A4 inhibition by clarithromycin reduces first-pass and systemic clearance of eletriptan
Cosa fare
Do not combine; choose an alternative to clarithromycin.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Eletriptan
- Almotriptan + Eletriptan Controindicata
- Atazanavir + Eletriptan Controindicata
- Ceritinib + Eletriptan Controindicata
- Cobicistat + Eletriptan Controindicata
- Conivaptan + Eletriptan Controindicata
- Darunavir + Eletriptan Controindicata
Domande frequenti
Can I take Clarithromycin with Eletriptan?
MediHelp rates the interaction as contraindicated. Clarithromycin and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin is a strong CYP3A4 inhibitor, and eletriptan is cleared largely by CYP3A4. Raised eletriptan exposure can lead to excessive eletriptan effect, including vasoconstriction and coronary spasm.
How serious is the interaction between Clarithromycin and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative to clarithromycin.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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