Interazioni tra farmaci
Clarithromycin + Lonafarnib
Gravità: Controindicata
Clarithromycin and Lonafarnib: contraindicated interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Lonafarnib is a sensitive CYP3A4 substrate and clarithromycin can greatly raise its levels, increasing the risk of toxicity including gastrointestinal effects, liver injury, and QT prolongation.
Cosa significa questa interazione in parole semplici
Clarithromycin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Lonafarnib belongs to Miscellaneous.
Perché avviene
Clarithromycin inhibits CYP3A4, decreasing lonafarnib clearance.
Cosa fare
Do not coadminister; use an alternative antibiotic, with ECG and liver function monitoring if exposure occurs.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Clarithromycin e Lonafarnib, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Lonafarnib
- Alfuzosin + Lonafarnib Controindicata
- Amobarbital + Lonafarnib Controindicata
- Apalutamide + Lonafarnib Controindicata
- Bosentan + Lonafarnib Controindicata
- Carbamazepine + Lonafarnib Controindicata
- Crizotinib + Lonafarnib Controindicata
Domande frequenti
Can I take Clarithromycin with Lonafarnib?
MediHelp rates the interaction as contraindicated. Clarithromycin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate and clarithromycin can greatly raise its levels, increasing the risk of toxicity including gastrointestinal effects, liver injury, and QT prolongation.
How serious is the interaction between Clarithromycin and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic, with ECG and liver function monitoring if exposure occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
