Interazioni tra farmaci
Clarithromycin + Vincristine
Gravità: Maggiore
Clarithromycin and Vincristine: major interaction.
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
Sintesi
Clarithromycin can raise vincristine levels and increase the risk of severe neurotoxicity, including neuropathy, ileus and seizures. Cases of enhanced toxicity have been described with strong CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Clarithromycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Vincristine belongs to Oncology.
Perché avviene
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of vincristine by clarithromycin.
Cosa fare
Avoid concomitant use and choose an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for neuropathy, constipation and CNS toxicity.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per sbloccare le indicazioni complete sulla gestione di Clarithromycin e Vincristine, le note aggiuntive, il dettaglio delle evidenze e il controllo delle interazioni per un'intera prescrizione.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Provi Pro+ gratis per 7 giorni sul web. Nessuna carta.
Altre interazioni di Clarithromycin
- Astemizole + Clarithromycin Controindicata
- Avanafil + Clarithromycin Controindicata
- Cisapride + Clarithromycin Controindicata
- Clarithromycin + Colchicine Controindicata
- Clarithromycin + Conivaptan Controindicata
- Clarithromycin + Dihydroergotamine Controindicata
Altre interazioni di Vincristine
- Adenovirus types 4 and 7 live + Vincristine Controindicata
- Apalutamide + Vincristine Maggiore
- Atazanavir + Vincristine Maggiore
- Ceritinib + Vincristine Maggiore
- Chloramphenicol + Vincristine Maggiore
- Cobicistat + Vincristine Maggiore
Domande frequenti
Can I take Clarithromycin with Vincristine?
MediHelp rates the interaction as major. Clarithromycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin can raise vincristine levels and increase the risk of severe neurotoxicity, including neuropathy, ileus and seizures. Cases of enhanced toxicity have been described with strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for neuropathy, constipation and CNS toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
