Interazioni tra farmaci
Clotrimazole + Cyclosporine
Gravità: Moderata
Clotrimazole and Cyclosporine: moderate interaction.
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Sintesi
Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
Cosa significa questa interazione in parole semplici
Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Clotrimazole may inhibit CYP3A4 and P-glycoprotein, reducing cyclosporine clearance.
Cosa fare
Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Clotrimazole
- Clotrimazole + Lomitapide Maggiore
- Clotrimazole + Mavacamten Maggiore
- Clotrimazole + Mobocertinib Maggiore
- Clotrimazole + Voclosporin Maggiore
- Bosutinib + Clotrimazole Moderata
- Cannabidiol + Clotrimazole Moderata
Domande frequenti
Can I take Clotrimazole with Cyclosporine?
MediHelp rates the interaction as moderate. Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
How serious is the interaction between Clotrimazole and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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