Interazioni tra farmaci
Cannabidiol + Clotrimazole
Gravità: Moderata
Cannabidiol and Clotrimazole: moderate interaction.
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Sintesi
Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
Cosa significa questa interazione in parole semplici
Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clotrimazole belongs to Anti Fungals.
Perché avviene
Inhibition of CYP3A4-mediated metabolism of cannabidiol by clotrimazole.
Cosa fare
Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Clotrimazole
- Clotrimazole + Lomitapide Maggiore
- Clotrimazole + Mavacamten Maggiore
- Clotrimazole + Mobocertinib Maggiore
- Clotrimazole + Voclosporin Maggiore
- Bosutinib + Clotrimazole Moderata
- Clotrimazole + Cyclosporine Moderata
Altre interazioni di Cannabidiol
- Cannabidiol + Phenytoin Maggiore
- Cannabidiol + Sodium valproate Maggiore
- Cannabidiol + Tacrolimus Maggiore
- Abiraterone + Cannabidiol Moderata
- Alogliptin-pioglitazone + Cannabidiol Moderata
- Amiodarone + Cannabidiol Moderata
Domande frequenti
Can I take Cannabidiol with Clotrimazole?
MediHelp rates the interaction as moderate. Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
How serious is the interaction between Cannabidiol and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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