Interazioni tra farmaci
Clozapine + Pefloxacin
Gravità: Maggiore
Clozapine and Pefloxacin: major interaction.
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Sintesi
Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.
Cosa significa questa interazione in parole semplici
Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
Perché avviene
Pefloxacin inhibits CYP1A2, decreasing clozapine clearance.
Cosa fare
Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Clozapine
- Clozapine + Deferiprone Controindicata
- Clozapine + Irinotecan Controindicata
- Clozapine + Pimozide Controindicata
- Clozapine + Thioridazine Controindicata
- Acalabrutinib + Clozapine Maggiore
- Adagrasib + Clozapine Maggiore
Altre interazioni di Pefloxacin
- Pefloxacin + Tizanidine Controindicata
- Duloxetine + Pefloxacin Maggiore
- Pefloxacin + Theophylline Maggiore
- Asenapine + Pefloxacin Moderata
- Caffeine + Pefloxacin Moderata
- Cimetidine + Pefloxacin Moderata
Domande frequenti
Can I take Clozapine with Pefloxacin?
MediHelp rates the interaction as major. Clozapine and Pefloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pefloxacin inhibits CYP1A2 and can raise clozapine concentrations, increasing the risk of sedation, hypotension, seizures, myocarditis and QT effects. Fluoroquinolones also have their own QT and seizure-lowering effects.
How serious is the interaction between Clozapine and Pefloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic that does not inhibit CYP1A2. If it must be used, reduce the clozapine dose and monitor clinical toxicity, clozapine levels and ECG.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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