Interazioni tra farmaci
Clozapine + Thioridazine
Gravità: Controindicata
Clozapine and Thioridazine: contraindicated interaction.
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Sintesi
Thioridazine prolongs the QTc interval dose-dependently and is contraindicated with other QT-prolonging drugs, and clozapine can also lengthen the QTc interval. Together they raise the risk of torsades de pointes and sudden cardiac death.
Cosa significa questa interazione in parole semplici
Clozapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clozapine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Perché avviene
Additive QTc prolongation (pharmacodynamic)
Cosa fare
Do not co-administer; choose an alternative that does not prolong the QT interval.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Thioridazine
- Abiraterone + Thioridazine Controindicata
- Adagrasib + Thioridazine Controindicata
- Amiodarone + Thioridazine Controindicata
- Amisulpride + Thioridazine Controindicata
- Amitriptyline + Thioridazine Controindicata
- Amoxapine + Thioridazine Controindicata
Altre interazioni di Clozapine
- Clozapine + Deferiprone Controindicata
- Clozapine + Irinotecan Controindicata
- Clozapine + Pimozide Controindicata
- Acalabrutinib + Clozapine Maggiore
- Adagrasib + Clozapine Maggiore
- Adrenaline-articaine + Clozapine Maggiore
Domande frequenti
Can I take Clozapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Clozapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine prolongs the QTc interval dose-dependently and is contraindicated with other QT-prolonging drugs, and clozapine can also lengthen the QTc interval. Together they raise the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Clozapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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