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Clozapine + Tolterodine

Gravità: Maggiore

Clozapine and Tolterodine: major interaction.

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Sintesi

Clozapine has strong antimuscarinic activity, and combining it with tolterodine raises the risk of severe constipation, paralytic ileus, urinary retention, tachycardia and delirium. Clozapine-related gastrointestinal hypomotility can be dangerous.

Cosa significa questa interazione in parole semplici

Clozapine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clozapine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.

Livello di evidenza: Moderate

Perché avviene

Additive antimuscarinic pharmacodynamic effects.

Cosa fare

Avoid the combination if possible, or monitor bowel function closely and treat constipation early. Consider non-anticholinergic options for overactive bladder, such as a beta-3 agonist.

Cosa chiedere al farmacista

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Clozapine with Tolterodine?

MediHelp rates the interaction as major. Clozapine and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine has strong antimuscarinic activity, and combining it with tolterodine raises the risk of severe constipation, paralytic ileus, urinary retention, tachycardia and delirium. Clozapine-related gastrointestinal hypomotility can be dangerous.

How serious is the interaction between Clozapine and Tolterodine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor bowel function closely and treat constipation early. Consider non-anticholinergic options for overactive bladder, such as a beta-3 agonist.

What other medicines interact with Tolterodine?

MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Cobicistat, Dronedarone. The full list is on the Tolterodine page.

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