Interazioni tra farmaci
Cobicistat + Flutamide
Gravità: Moderata
Cobicistat and Flutamide: moderate interaction.
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Sintesi
Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
Cosa significa questa interazione in parole semplici
Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Flutamide belongs to Endocrine.
Perché avviene
Cobicistat inhibits CYP3A4, reducing metabolism of flutamide and its metabolites.
Cosa fare
Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Flutamide
- Flutamide + Idelalisib Maggiore
- Flutamide + Levoketoconazole Maggiore
- Flutamide + Pexidartinib Maggiore
- Flutamide + Pretomanid Maggiore
- Flutamide + Valoctocogene roxaparvovec Maggiore
- Apalutamide + Flutamide Moderata
Altre interazioni di Cobicistat
- Alfuzosin + Cobicistat Controindicata
- Apalutamide + Cobicistat Controindicata
- Cobicistat + Colchicine Controindicata
- Cobicistat + Dronedarone Controindicata
- Cobicistat + Eletriptan Controindicata
- Cobicistat + Eplerenone Controindicata
Domande frequenti
Can I take Cobicistat with Flutamide?
MediHelp rates the interaction as moderate. Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
How serious is the interaction between Cobicistat and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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