Drug interactions
Cobicistat + Flutamide
Severity: Moderate
Cobicistat and Flutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
What this interaction means in plain words
Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Flutamide belongs to Endocrine.
Why it happens
Cobicistat inhibits CYP3A4, reducing metabolism of flutamide and its metabolites.
What to do
Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cobicistat and Flutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Flutamide
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Flutamide?
MediHelp rates the interaction as moderate. Cobicistat and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and may raise flutamide exposure, although flutamide is mainly cleared by CYP1A2. Higher levels of flutamide or its metabolites could increase the risk of hepatotoxicity.
How serious is the interaction between Cobicistat and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and counsel patients on symptoms of liver injury. Consider an alternative antiandrogen or antiretroviral if abnormalities arise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
