Interazioni tra farmaci
Cobicistat + Midazolam
Gravità: Controindicata
Cobicistat and Midazolam: contraindicated interaction.
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Sintesi
Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
Cosa significa questa interazione in parole semplici
Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Perché avviene
Cobicistat inhibits intestinal and hepatic CYP3A4, blocking midazolam first-pass and systemic metabolism.
Cosa fare
Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Midazolam
- Atazanavir + Midazolam Controindicata
- Darunavir + Midazolam Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Controindicata
- Fosamprenavir + Midazolam Controindicata
- Indinavir + Midazolam Controindicata
- Itraconazole + Midazolam Controindicata
Altre interazioni di Cobicistat
- Alfuzosin + Cobicistat Controindicata
- Apalutamide + Cobicistat Controindicata
- Cobicistat + Colchicine Controindicata
- Cobicistat + Dronedarone Controindicata
- Cobicistat + Eletriptan Controindicata
- Cobicistat + Eplerenone Controindicata
Domande frequenti
Can I take Cobicistat with Midazolam?
MediHelp rates the interaction as contraindicated. Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
How serious is the interaction between Cobicistat and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Midazolam page.
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