Interazioni tra farmaci
Itraconazole + Midazolam
Gravità: Controindicata
Itraconazole and Midazolam: contraindicated interaction.
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Sintesi
Itraconazole is a strong CYP3A4 inhibitor and raises midazolam exposure many-fold, especially with the oral route. Prolonged sedation and respiratory depression can occur.
Cosa significa questa interazione in parole semplici
Itraconazole and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Perché avviene
Strong CYP3A4 inhibition markedly raises midazolam exposure
Cosa fare
Oral midazolam is contraindicated; if IV midazolam is unavoidable, use a reduced dose with continuous monitoring.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Itraconazole
- Alfuzosin + Itraconazole Controindicata
- Alprazolam + Itraconazole Controindicata
- Avanafil + Itraconazole Controindicata
- Conivaptan + Itraconazole Controindicata
- Dihydroergotamine intranasal + Itraconazole Controindicata
- Dihydroergotamine + Itraconazole Controindicata
Altre interazioni di Midazolam
- Atazanavir + Midazolam Controindicata
- Cobicistat + Midazolam Controindicata
- Darunavir + Midazolam Controindicata
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Controindicata
- Fosamprenavir + Midazolam Controindicata
- Indinavir + Midazolam Controindicata
Domande frequenti
Can I take Itraconazole with Midazolam?
MediHelp rates the interaction as contraindicated. Itraconazole and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole is a strong CYP3A4 inhibitor and raises midazolam exposure many-fold, especially with the oral route. Prolonged sedation and respiratory depression can occur.
How serious is the interaction between Itraconazole and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Oral midazolam is contraindicated; if IV midazolam is unavoidable, use a reduced dose with continuous monitoring.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
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