Interazioni tra farmaci
Cyclobenzaprine + Tranylcypromine
Gravità: Controindicata
Cyclobenzaprine and Tranylcypromine: contraindicated interaction.
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Sintesi
Tranylcypromine inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
Cosa significa questa interazione in parole semplici
Cyclobenzaprine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclobenzaprine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Perché avviene
Additive serotonergic activity: irreversible non-selective MAO inhibition plus monoamine reuptake inhibition
Cosa fare
Do not combine; allow at least 14 days after stopping the tranylcypromine before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the tranylcypromine.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Controindicata
- Cyclobenzaprine + Linezolid Controindicata
- Cyclobenzaprine + Phenelzine Controindicata
- Cyclobenzaprine + Safinamide Controindicata
- Cyclobenzaprine + Selegiline Controindicata
- Cyclobenzaprine + Selegiline transdermal Controindicata
Altre interazioni di Tranylcypromine
- 5-HTP + Tranylcypromine Controindicata
- Amitriptyline + Tranylcypromine Controindicata
- Amoxapine + Tranylcypromine Controindicata
- Atomoxetine + Tranylcypromine Controindicata
- Benzphetamine + Tranylcypromine Controindicata
- Brimonidine + Tranylcypromine Controindicata
Domande frequenti
Can I take Cyclobenzaprine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Cyclobenzaprine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine inhibits monoamine oxidase and so reduces serotonin breakdown, while cyclobenzaprine is a tricyclic-related muscle relaxant that inhibits serotonin and norepinephrine reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Cyclobenzaprine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the tranylcypromine before starting cyclobenzaprine, and at least 14 days after stopping cyclobenzaprine before starting the tranylcypromine.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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