Interazioni tra farmaci
Cyclosporine + Liposomal doxorubicin
Gravità: Maggiore
Cyclosporine and Liposomal doxorubicin: major interaction.
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Sintesi
Cyclosporine inhibits P-glycoprotein and CYP3A4 and has been reported to increase doxorubicin exposure and toxicity, including myelosuppression. Cases of severe neutropenia and neurotoxicity have been reported with the combination of anthracyclines and cyclosporine. Additive immunosuppression further raises infection risk.
Cosa significa questa interazione in parole semplici
Cyclosporine and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Cyclosporine inhibits P-gp and CYP3A4, reducing doxorubicin clearance, with additive immunosuppression.
Cosa fare
Monitor blood counts, cardiac function and signs of infection closely, and consider reducing the doxorubicin dose. Avoid the combination when alternatives exist.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Controindicata
- Belatacept + Liposomal doxorubicin Maggiore
- Dronedarone + Liposomal doxorubicin Maggiore
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Maggiore
- Fingolimod + Liposomal doxorubicin Maggiore
- Ganciclovir + Liposomal doxorubicin Maggiore
Domande frequenti
Can I take Cyclosporine with Liposomal doxorubicin?
MediHelp rates the interaction as major. Cyclosporine and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits P-glycoprotein and CYP3A4 and has been reported to increase doxorubicin exposure and toxicity, including myelosuppression. Cases of severe neutropenia and neurotoxicity have been reported with the combination of anthracyclines and cyclosporine. Additive immunosuppression further raises infection risk.
How serious is the interaction between Cyclosporine and Liposomal doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, cardiac function and signs of infection closely, and consider reducing the doxorubicin dose. Avoid the combination when alternatives exist.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Dronedarone. The full list is on the Liposomal doxorubicin page.
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