Interazioni tra farmaci
Cyclosporine + Rifaximin
Gravità: Moderata
Cyclosporine and Rifaximin: moderate interaction.
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Sintesi
Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
Cosa significa questa interazione in parole semplici
Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perché avviene
Cyclosporine inhibition of P-glycoprotein markedly increases rifaximin absorption.
Cosa fare
Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Rifaximin
- Cholera vaccine + Rifaximin Maggiore
- Microbiota + Rifaximin Maggiore
- Amiodarone + Rifaximin Moderata
- Bcg intravesical live + Rifaximin Moderata
- Cyclosporin + Rifaximin Moderata
- Dronedarone + Rifaximin Moderata
Domande frequenti
Can I take Cyclosporine with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
How serious is the interaction between Cyclosporine and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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