Interazioni tra farmaci
Cyclosporin + Rifaximin
Gravità: Moderata
Cyclosporin and Rifaximin: moderate interaction.
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Sintesi
Cyclosporine markedly increases systemic absorption of rifaximin, which is normally minimally absorbed. In patients with intact gut barrier this has been very large, and the consequences of such exposure are not well defined.
Cosa significa questa interazione in parole semplici
Cyclosporin and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Rifaximin belongs to Anti Bacterial.
Perché avviene
Cyclosporine inhibits P-glycoprotein, which limits rifaximin absorption, greatly increasing systemic rifaximin levels.
Cosa fare
Avoid combining where possible, particularly in patients with severe hepatic impairment. If used, monitor for adverse effects of rifaximin and for changes in cyclosporine levels.
Cosa chiedere al farmacista
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Rifaximin
- Cholera vaccine + Rifaximin Maggiore
- Microbiota + Rifaximin Maggiore
- Amiodarone + Rifaximin Moderata
- Bcg intravesical live + Rifaximin Moderata
- Cyclosporine + Rifaximin Moderata
- Dronedarone + Rifaximin Moderata
Domande frequenti
Can I take Cyclosporin with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporin and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine markedly increases systemic absorption of rifaximin, which is normally minimally absorbed. In patients with intact gut barrier this has been very large, and the consequences of such exposure are not well defined.
How serious is the interaction between Cyclosporin and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, particularly in patients with severe hepatic impairment. If used, monitor for adverse effects of rifaximin and for changes in cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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