Interazioni tra farmaci
Daunorubicin + Trastuzumab deruxtecan
Gravità: Maggiore
Daunorubicin and Trastuzumab deruxtecan: major interaction.
Ultimo aggiornamento
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Sintesi
Anthracyclines and HER2-directed antibodies both carry cardiotoxicity risk, and giving them together or in close sequence increases the risk of cardiomyopathy and reduced ejection fraction. Trastuzumab deruxtecan also causes interstitial lung disease and myelosuppression.
Cosa significa questa interazione in parole semplici
Daunorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Perché avviene
Additive cardiotoxicity from anthracycline myocardial injury and HER2 pathway inhibition in cardiomyocytes.
Cosa fare
Avoid concurrent use and keep the interval between anthracycline and HER2-directed therapy as long as possible. Assess left ventricular ejection fraction before and regularly during treatment.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Controindicata
- Belatacept + Daunorubicin Maggiore
- Cyclosporine + Daunorubicin Maggiore
- Cyclosporin + Daunorubicin Maggiore
- Daunorubicin + Dengue vaccine Maggiore
- Daunorubicin + Etrasimod Maggiore
Altre interazioni di Trastuzumab deruxtecan
Domande frequenti
Can I take Daunorubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Daunorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anthracyclines and HER2-directed antibodies both carry cardiotoxicity risk, and giving them together or in close sequence increases the risk of cardiomyopathy and reduced ejection fraction. Trastuzumab deruxtecan also causes interstitial lung disease and myelosuppression.
How serious is the interaction between Daunorubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep the interval between anthracycline and HER2-directed therapy as long as possible. Assess left ventricular ejection fraction before and regularly during treatment.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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