Interazioni tra farmaci
Cyclosporin + Daunorubicin
Gravità: Maggiore
Cyclosporin and Daunorubicin: major interaction.
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Sintesi
Cyclosporine can increase daunorubicin exposure and prolong its effects, increasing myelosuppression, mucositis and cardiotoxicity. It has been used deliberately to overcome drug resistance, which requires dose consideration.
Cosa significa questa interazione in parole semplici
Cyclosporin and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Daunorubicin belongs to Oncology.
Perché avviene
Cyclosporine inhibits P-glycoprotein efflux, reducing daunorubicin clearance.
Cosa fare
Monitor blood counts and cardiac function closely and consider reducing the daunorubicin dose.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Controindicata
- Aliskiren + Cyclosporin Controindicata
- Bcg vaccine live + Cyclosporin Controindicata
- Bosentan + Cyclosporin Controindicata
- Cidofovir + Cyclosporin Controindicata
- Cyclosporin + Dengue vaccine Controindicata
Altre interazioni di Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Controindicata
- Belatacept + Daunorubicin Maggiore
- Cyclosporine + Daunorubicin Maggiore
- Daunorubicin + Dengue vaccine Maggiore
- Daunorubicin + Etrasimod Maggiore
- Daunorubicin + Fingolimod Maggiore
Domande frequenti
Can I take Cyclosporin with Daunorubicin?
MediHelp rates the interaction as major. Cyclosporin and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase daunorubicin exposure and prolong its effects, increasing myelosuppression, mucositis and cardiotoxicity. It has been used deliberately to overcome drug resistance, which requires dose consideration.
How serious is the interaction between Cyclosporin and Daunorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely and consider reducing the daunorubicin dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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