Interazioni tra farmaci
Defibrotide + Edoxaban
Gravità: Controindicata
Defibrotide and Edoxaban: contraindicated interaction.
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Sintesi
Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
Cosa significa questa interazione in parole semplici
Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Perché avviene
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition and defibrotide's profibrinolytic activity.
Cosa fare
Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Edoxaban
- Apixaban + Edoxaban Controindicata
- Edoxaban + Ketorolac Controindicata
- Abciximab + Edoxaban Maggiore
- Acetylsalicylic acid + Edoxaban Maggiore
- Argatroban + Edoxaban Maggiore
- Aspirin rectal + Edoxaban Maggiore
Altre interazioni di Defibrotide
- Alteplase + Defibrotide Controindicata
- Apixaban + Defibrotide Controindicata
- Argatroban + Defibrotide Controindicata
- Dabigatran etexilate + Defibrotide Controindicata
- Dalteparin + Defibrotide Controindicata
- Defibrotide + Enoxaparin Controindicata
Domande frequenti
Can I take Defibrotide with Edoxaban?
MediHelp rates the interaction as contraindicated. Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
How serious is the interaction between Defibrotide and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Ketorolac, Abciximab. The full list is on the Edoxaban page.
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