Interazioni tra farmaci
Dexamethasone-neomycin-polymyxin + Mifepristone
Gravità: Maggiore
Dexamethasone-neomycin-polymyxin and Mifepristone: major interaction.
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Sintesi
Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
Cosa significa questa interazione in parole semplici
Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Perché avviene
Glucocorticoid receptor antagonism by mifepristone plus CYP3A4 inhibition of dexamethasone metabolism.
Cosa fare
With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Maggiore
- Dexamethasone-neomycin-polymyxin + Lapatinib Maggiore
- Dexamethasone-neomycin-polymyxin + Levofloxacin Maggiore
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Maggiore
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderata
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Moderata
Altre interazioni di Mifepristone
- Apixaban + Mifepristone Controindicata
- Argatroban + Mifepristone Controindicata
- Cisapride + Mifepristone Controindicata
- Cortisone + Mifepristone Controindicata
- Cyclosporin + Mifepristone Controindicata
- Dabigatran etexilate + Mifepristone Controindicata
Domande frequenti
Can I take Dexamethasone-neomycin-polymyxin with Mifepristone?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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