Interazioni tra farmaci
Dexamethasone-neomycin-polymyxin + Moxifloxacin
Gravità: Maggiore
Dexamethasone-neomycin-polymyxin and Moxifloxacin: major interaction.
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Sintesi
Fluoroquinolones given with systemic corticosteroids increase the risk of tendinitis and tendon rupture. Older age and long treatment raise the risk further.
Cosa significa questa interazione in parole semplici
Dexamethasone-neomycin-polymyxin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Moxifloxacin belongs to Anti Bacterial.
Perché avviene
Additive tendon toxicity from fluoroquinolone effects on tenocytes and corticosteroid impairment of collagen synthesis.
Cosa fare
Avoid the combination in older patients where an alternative antibiotic exists. Discontinue moxifloxacin at the first sign of tendon pain.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Maggiore
- Dexamethasone-neomycin-polymyxin + Lapatinib Maggiore
- Dexamethasone-neomycin-polymyxin + Levofloxacin Maggiore
- Dexamethasone-neomycin-polymyxin + Mifepristone Maggiore
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderata
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Moderata
Altre interazioni di Moxifloxacin
- Amiodarone + Moxifloxacin Controindicata
- Arsenic trioxide + Moxifloxacin Controindicata
- Disopyramide + Moxifloxacin Controindicata
- Dofetilide + Moxifloxacin Controindicata
- Dronedarone + Moxifloxacin Controindicata
- Droperidol + Moxifloxacin Controindicata
Domande frequenti
Can I take Dexamethasone-neomycin-polymyxin with Moxifloxacin?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones given with systemic corticosteroids increase the risk of tendinitis and tendon rupture. Older age and long treatment raise the risk further.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where an alternative antibiotic exists. Discontinue moxifloxacin at the first sign of tendon pain.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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