Interazioni tra farmaci
Diltiazem + Lonafarnib
Gravità: Controindicata
Diltiazem and Lonafarnib: contraindicated interaction.
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Sintesi
Lonafarnib is a sensitive CYP3A4 substrate, and diltiazem as a moderate CYP3A4 inhibitor can substantially increase its exposure. This raises the risk of lonafarnib toxicity, including gastrointestinal effects, renal and hepatic toxicity, and QT-related concerns. Labeling advises against use with moderate or strong CYP3A4 inhibitors.
Cosa significa questa interazione in parole semplici
Diltiazem and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Diltiazem belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.
Perché avviene
Diltiazem inhibits CYP3A4, reducing the metabolic clearance of lonafarnib.
Cosa fare
Avoid the combination and select a non-CYP3A4-inhibiting alternative to diltiazem. If unavoidable, follow labeling dose-reduction guidance and monitor closely for toxicity.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Altre interazioni di Diltiazem
- Diltiazem + Flibanserin Controindicata
- Diltiazem + Ivabradine Controindicata
- Diltiazem + Lomitapide Controindicata
- Acebutolol + Diltiazem Maggiore
- Alfentanil + Diltiazem Maggiore
- Amifostine + Diltiazem Maggiore
Altre interazioni di Lonafarnib
- Alfuzosin + Lonafarnib Controindicata
- Amobarbital + Lonafarnib Controindicata
- Apalutamide + Lonafarnib Controindicata
- Bosentan + Lonafarnib Controindicata
- Carbamazepine + Lonafarnib Controindicata
- Clarithromycin + Lonafarnib Controindicata
Domande frequenti
Can I take Diltiazem with Lonafarnib?
MediHelp rates the interaction as contraindicated. Diltiazem and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and diltiazem as a moderate CYP3A4 inhibitor can substantially increase its exposure. This raises the risk of lonafarnib toxicity, including gastrointestinal effects, renal and hepatic toxicity, and QT-related concerns. Labeling advises against use with moderate or strong CYP3A4 inhibitors.
How serious is the interaction between Diltiazem and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-CYP3A4-inhibiting alternative to diltiazem. If unavoidable, follow labeling dose-reduction guidance and monitor closely for toxicity.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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