Interazioni tra farmaci
Disulfiram + Tinidazole
Gravità: Controindicata
Disulfiram and Tinidazole: contraindicated interaction.
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Sintesi
Tinidazole labeling advises against use within two weeks of disulfiram. The combination has been associated with psychotic reactions and confusion, and a disulfiram-like reaction with alcohol is also a concern.
Cosa significa questa interazione in parole semplici
Disulfiram and Tinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Perché avviene
Additive central nervous system toxicity; the exact mechanism is not established.
Cosa fare
Do not give tinidazole to patients who have taken disulfiram in the past two weeks. Choose an alternative antimicrobial.
Cosa chiedere al farmacista
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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- Additional notes
- Evidence detail
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Altre interazioni di Tinidazole
- Ethanol + Tinidazole Maggiore
- Fexinidazole + Tinidazole Maggiore
- Lopinavir + Tinidazole Maggiore
- Nilotinib + Tinidazole Maggiore
- Ritonavir + Tinidazole Maggiore
- Amiodarone + Tinidazole Moderata
Domande frequenti
Can I take Disulfiram with Tinidazole?
MediHelp rates the interaction as contraindicated. Disulfiram and Tinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tinidazole labeling advises against use within two weeks of disulfiram. The combination has been associated with psychotic reactions and confusion, and a disulfiram-like reaction with alcohol is also a concern.
How serious is the interaction between Disulfiram and Tinidazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give tinidazole to patients who have taken disulfiram in the past two weeks. Choose an alternative antimicrobial.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Ethanol, Fexinidazole, Lopinavir. The full list is on the Tinidazole page.
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