Drug interactions
Disulfiram + Tinidazole
Severity: Contraindicated
Disulfiram and Tinidazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tinidazole labeling advises against use within two weeks of disulfiram. The combination has been associated with psychotic reactions and confusion, and a disulfiram-like reaction with alcohol is also a concern.
What this interaction means in plain words
Disulfiram and Tinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive central nervous system toxicity; the exact mechanism is not established.
What to do
Do not give tinidazole to patients who have taken disulfiram in the past two weeks. Choose an alternative antimicrobial.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tinidazole
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
- Amiodarone + Tinidazole Moderate
Frequently asked questions
Can I take Disulfiram with Tinidazole?
MediHelp rates the interaction as contraindicated. Disulfiram and Tinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tinidazole labeling advises against use within two weeks of disulfiram. The combination has been associated with psychotic reactions and confusion, and a disulfiram-like reaction with alcohol is also a concern.
How serious is the interaction between Disulfiram and Tinidazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give tinidazole to patients who have taken disulfiram in the past two weeks. Choose an alternative antimicrobial.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Ethanol, Fexinidazole, Lopinavir. The full list is on the Tinidazole page.
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