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Interazioni tra farmaci

Dopamine + Selegiline transdermal

Gravità: Controindicata

Dopamine and Selegiline transdermal: contraindicated interaction.

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Sintesi

Selegiline is a monoamine oxidase inhibitor, and inhibited MAO greatly potentiates the pressor effect of dopamine. This may cause severe hypertensive crisis.

Cosa significa questa interazione in parole semplici

Dopamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Livello di evidenza: Moderate

Perché avviene

MAO inhibition reduces dopamine breakdown and increases norepinephrine stores, amplifying sympathomimetic effects.

Cosa fare

Avoid; if dopamine is essential, stop selegiline and use a markedly reduced starting dose with close blood pressure monitoring only in an emergency.

Cosa chiedere al farmacista

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Domande frequenti

Can I take Dopamine with Selegiline transdermal?

MediHelp rates the interaction as contraindicated. Dopamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is a monoamine oxidase inhibitor, and inhibited MAO greatly potentiates the pressor effect of dopamine. This may cause severe hypertensive crisis.

How serious is the interaction between Dopamine and Selegiline transdermal?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; if dopamine is essential, stop selegiline and use a markedly reduced starting dose with close blood pressure monitoring only in an emergency.

What other medicines interact with Dopamine?

MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Amitriptyline. The full list is on the Dopamine page.

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